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Rational Therapeutics
Dr. Nagourney
Dr. Nagourney is a world renowned Cancer Researcher and the director of the Rational Therapeutics Cancer Evaluation Center in Long Beach, CA.
With more than 18 years of experience in the assessment of drug radiation and biological agent effects in primary cultures of human tissue, Rational Therapeutics utilizes the most valid and clinically correlated ex-vivo assay method available. Currently, Dr. Nagourney has more than 500 published, peer-reviewed clinical correlations in world literature.
What is Ex-Vivo Testing?
A live, fresh tumor specimen or blood sample is taken from the patient and tested (ex-vivo) to determine the tumor's sensitivity to an array of drug, radiation and biological agents in apoptosis-based primary cultures of human tissue. Each agent is diluted to the point where it is still IC50 (meaning, it kills at least 50% of cancer cells.) After reviewing the results, the patient along with his doctor, can plan a more effective course of treatment.
In 1996 Dr. Nagourney requested several vials of Alsihum. His interest in Alsihum was piqued when one of his clients requested that Alsihum be evaluate along with several other well-known treatments. The results of this initial evaluation were as follows:
Ex-Vivo Drug Sensitivity Report:
DRUG
NIT MUSTARD
DOXORUBICIN
CISPLATIN
VP 16
TAXOL
GEMCITABINE
VINORELBINE
MITOXANTRONE
DEXAMETHASONE
CYTARIBINE
FLUDARABINE
CDDP/ ARAC
CDDP/ FLUD
2-CDA
NIT MUST/ 2DA
TOPOTECAN
VINCRISTINE
ALZIUM*
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LC 50 (ug/ml)
0.9
0.009
10.9
6.4
2.2
18.9 nMOLAR
2.65
0.04
<.25
0.37
1.0
N/A
N/A
204nMOLAR
N/A
500nMOLAR
<.04
STOCK X 0.0057
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note: lower numbers indicate a more powerful compound
Interpretation: Results clearly indicate a LC50 of cancerous cells killed. (Meaning that more than 50% of the cancerous cells are killed even when diluting Alzium at 57/10,000!) Alsihum* also rated better than any of the other known and tested agents.
Considering these fascinating results, Dr. Nagourney believes that Alsihum* warrants further investigation. The research team at CED TECH HEALTH LTD. is looking forward to conducting further clinical trials in conjunction with Rational Therapeutics in the future.
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