Plant extracts A, C, E and F had moderate activity, IC50 at about 1% plant extract. Plant extracts B and D were least cytotoxic at IC50 of about 2.5%.

All plant extracts were tested in at least HCT8 tumor cells and normal fibroblasts. Plant extracts E, F and G were also tested in all 4 cell lines including U138 and U87 gliomas. Plant extract G was much less toxic to CMH-F1 fibroblasts and U138 glioma. In other recent experimental chemotherapy studies, we are finding that U138 glioma cells are highly resistant to the plant-derived anticancer drug, etoposide. Similar results were seen for plant extracts E and F. Although plant extract A was moderately cytotoxic to HCT8, it was exceptionally inactive against fibroblasts. Further experiments were conducted with plant extracts A, F, G and H in two fibroblasts cell lines.

The following information is in abridged format

Cytotoxic effects of plant extracts in non-tumor CMH-F1 skin fibroblasts cells:
Low sensitivities were observed for 4 plant extracts. 2 extracts (G and H) were the most cytotoxic at IC50's of 0.6 to 0.9%. Plant extracts A and F were several times less active.

Cytotoxic effects of plant extracts in multi-drug resistant SW1573-2R160 lung cancer cells:
In this test (data not shown) there was no evidence of drug resistance to the degree found for those natural product drugs including antibiotics, vinca alkaloids, epipodophyllotoxins and taxol. The plant extract substances tested do not appear to be subject to expulsion from cells by the transmembrane efflux pump (mdr-1 gene product).

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